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We have been studying the p53 tumor surpressor and our first results have recently been published. To our knowledge, this is the first peer-reviewed results from a distributed computing project related to cancer. Thanks to the continued support of FAH donors, this is will be just the first of many cancer related works that will come from FAH.

The nature of our results can best be described in our paper. However, here's a brief summary of our results. Roughly half of all known cancers result from mutations in p53. Our first work in the cancer area examines the tetramerization domain of p53. We predict how p53 folds and in doing so, we can predict which amino acid mutations would be relevant. When compared with experiments, our predictions have appeared to agree with experiment and give a new interpretation to existing data.

Thanks to all who have helped make this possible.

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Professor Vijay S. Pande, PhD
Director, Folding@Home Distributed Computing Project, and
Assistant Professor of Chemistry and of Structural Biology, Stanford University

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Very ok day. Almost 5,000 points for the week already.

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Who worries about points? says the guy who is only getting 77 point work units or less each day